How Cannabis was Used to Shrink one of the Most Aggressive Brain Cancers

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Other uses. Jordan Greentree, CC BY-SA

 Courtesy of The Conversation:

Widely proscribed around the world for its recreational uses, cannabis is being used in a number of different therapeutic ways to bring relief for severe medical conditions. Products using cannabinoids, the active components of the cannabis plant, have been licensed for medical use. Sativex, for example, which contains an equal mixture of the cannabinoids tetrahydrocannabinol (THC) and cannabidiol (CBD), is already licenced as a mouth spray for multiple sclerosis and in the US, dronabinol and nabilone are commercially available for treating cancer-related side effects.

Now, in a study published in Molecular Cancer Therapeutics, we’ve also shown that cannabinoids could play a role in treating one of the most aggressive cancers in adults.

There are more than 85 cannabinoids, which are known to bind to unique receptors in cells and which receive outside chemical signals. These receptors feed into signalling pathways, telling cells what to do. Recent studies have shown that some cannabinoids have potent anti-cancer action. For example, both THC and CBD have been shown in a number of laboratory studies to effectively induce cell death in tumour cells by modifying the faulty signalling pathways inside these cells. Depending on the cell type this can disrupt tumour growth or start to kill it.

The psychoactivity associated with some cannabinoids, principally THC (which gives people a cannabis high), is also mediated via the same receptors. Because these receptors are found in the highest abundances in brain cells, it follows that brain tumours also rich in these receptors may respond best to cannabinoids. Continue reading

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Molecular Biologist Explains How THC Kills Cancer Completely

Courtesy of Natural Society:

From Compultense University in Madrid, Spain, Dr. Christina Sanchez has been studying the anti-tumor effects of THC, the main psychoactive component of cannabis, for over a decade. She delivers sound information that explains exactly how THC kills cancer cells entirely – without adverse effects to healthy cells.

Her research is an addition to other’s work, such as British scientist, Wai Liu, an oncologist at the University of London’s St. George’s medical school. Liu’s research also reveals how THC has ‘potent anti-cancer activity,’ and can significantly ‘target and switch off’ pathways that allow cancers to grow.

Liu points out that pharmaceutical companies spend billions on drugs that do the very same thing, while the cannabis plant does it naturally. In the following video, Dr. Sanchez explains exactly how THC does the dirty work of eliminating cancer cells by activating the body’s own cannabinoid receptors, creating endocannabinoids. What’s more, is cannabis can do this without any psychoactive effects.

“There’s quite a lot of cancers that should respond quite nicely to these cannabis agents,” Liu said. “If you talk about a drug company that spent billions of pounds trying to develop these new drugs that target these pathways, cannabis does exactly the same thing – or certain elements of cannabis compounds do exactly the same thing – so you have something that is naturally produced which impacts the same pathways that these fantastic drugs that cost billions also work on.”

This comes at an important time when states are legalizing medical marijuana and the federal government is receiving pressure to de-list cannabis as an illegal drug – an archaic and erroneous definition of a plant which the Feds say ‘has no medicinal value’, even though they hold numerous patents on the plant. The feds are still fighting marijuana, despite having numerous patents on the plant. Continue reading

34 Medical Studies Proving Cannabis Cures Cancer

Courtesy of Waking Times:

There’s still a lot of confusion across the nation about whether or not marijuana is effective for cancer patients. Odds are you’ve heard something about it but weren’t sure whether the information was reliable or definitive. So, in order to help clear things up, here is a list of 34 studies showing that marijuana cures cancer, categorized by the type of cancers being cured in each study. As you sort through the articles, note that the consistent theme between them is that cannabis shrinks tumors and selectively targets cancer cells. As bills and voter initiatives to legalize medical marijuana spread from state to state, remember that we’re not just talking about mitigating the side effects of chemo (though this is another viable use), we’re talking about curing the cancer itself as well as preventing its spread. I’ve taken the liberty of only including articles from credible scientific journals, removing any biased or otherwise improperly cited studies. Enjoy!

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Cures Brain Cancer

http://www.nature.com/bjc/journal/v95/n2/abs/6603236a.html

http://www.ncbi.nlm.nih.gov/pubmed/11479216

http://www.jneurosci.org/content/21/17/6475.abstract

http://jpet.aspetjournals.org/content/308/3/838.abstract

http://mct.aacrjournals.org/content/10/1/90.abstract

Cures Mouth and Throat Cancer

http://www.ncbi.nlm.nih.gov/pubmed/20516734

Cures Breast Cancer

http://www.ncbi.nlm.nih.gov/pubmed/20859676

http://www.ncbi.nlm.nih.gov/pubmed/18025276

http://www.ncbi.nlm.nih.gov/pubmed/21915267

http://jpet.aspetjournals.org/content/early/2006/05/25/jpet.106.105247.full.pdf+html

http://www.molecular-cancer.com/content/9/1/196

http://www.ncbi.nlm.nih.gov/pubmed/22776349

http://www.pnas.org/content/95/14/8375.full.pdf+html

Cures Lung Cancer

http://www.ncbi.nlm.nih.gov/pubmed/22198381?dopt=Abstract

http://www.ncbi.nlm.nih.gov/pubmed/21097714?dopt=Abstract

http://www.nature.com/onc/journal/v27/n3/abs/1210641a.html

Cures Uterine, Testicular, and Pancreatic Cancers

http://www.cancer.gov/cancertopics/pdq/cam/cannabis/healthprofessional/page4

http://cancerres.aacrjournals.org/content/66/13/6748.abstract

Cures Prostate Cancer

http://www.ncbi.nlm.nih.gov/pubmed/12746841?dopt=Abstract

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339795/?tool=pubmed

http://www.ncbi.nlm.nih.gov/pubmed/22594963

Cures Colorectal Cancer

http://www.ncbi.nlm.nih.gov/pubmed/22231745

Cures Ovarian Cancer

http://www.aacrmeetingabstracts.org/cgi/content/abstract/2006/1/1084

Cures Blood Cancer

http://www.ncbi.nlm.nih.gov/pubmed/12091357

http://www.ncbi.nlm.nih.gov/pubmed/16908594

http://onlinelibrary.wiley.com/doi/10.1002/ijc.23584/abstract

http://molpharm.aspetjournals.org/content/70/5/1612.abstract

Cures Skin Cancer

http://www.ncbi.nlm.nih.gov/pubmed/12511587

Cures Liver Cancer

http://www.ncbi.nlm.nih.gov/pubmed/21475304

Cures Biliary Tract Cancer

http://www.ncbi.nlm.nih.gov/pubmed/19916793

Cures Bladder Cancer

http://www.medscape.com/viewarticle/803983 (Sign-up required to view study)

Cures Cancer in General

http://www.ncbi.nlm.nih.gov/pubmed/12514108

http://www.ncbi.nlm.nih.gov/pubmed/15313899

http://www.ncbi.nlm.nih.gov/pubmed/15313899

Study shows non-hallucinogenic cannabinoids are effective anti-cancer drugs

Courtesy of Alpha Galileo:

New research has shown that the non-hallucinogenic components of cannabis could act as effective anti-cancer agents.

The anti-cancer properties of tetrahydrocannabinol (THC), the primary hallucinogenic component of cannabis, has been recognised for many years, but research into similar cannabis-derived compounds, known as cannabinoids, has been limited.

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The study was carried out by a team at St George’s, University of London. It has been published in the journal Anticancer Research. Continue reading

Government Report Offers More Evidence Cannabis is a Wonder Drug for Cancer and Good Health

Courtesy of Rise Earth:

As the world’s most beloved herb, Cannabis, continues to be liberated from the persecution of the government and the pharmaceutical-industrial complex, research continues to validate the many health benefits of Cannabis. This time, The National Cancer Institute, a government-funded organization has released a report indicating that cannabis and cannabinoids are indeed powerful agents of good health and wonderful supplements in the fight against cancer.

“Cannabis use for medicinal purposes dates back at least 3,000 years.[1-5] It was introduced into Western medicine in the 1840s by W.B. O’Shaughnessy, a surgeon who learned of its medicinal properties while working in India for the British East Indies Company. Its use was promoted for reported analgesic, sedative, anti-inflammatory, antispasmodic, and anticonvulsant effects.

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In 1937, the U.S. Treasury Department introduced the Marihuana Tax Act. This Act imposed a levy of $1 per ounce for medicinal use of Cannabis and $100 per ounce for recreational use. Physicians in the United States were the principal opponents of the Act. The American Medical Association (AMA) opposed the Act because physicians were required to pay a special tax for prescribing Cannabis, use special order forms to procure it, and keep special records concerning its professional use. In addition, the AMA believed that objective evidence that Cannabis was harmful was lacking and that passage of the Act would impede further research into its medicinal worth.[6] In 1942, Cannabis was removed from the U.S. Pharmacopoeia because of persistent concerns about its potential to cause harm.[2,3]

In 1951, Congress passed the Boggs Act, which for the first time, included Cannabis with narcoticdrugs. In 1970, with the passage of the Controlled Substances Act, marijuana was classified as a Schedule I drug. Drugs in this category are distinguished as having no accepted medicinal use. Other Schedule I substances include heroin, LSD, mescaline, methaqualone, and gamma-hydroxybutyrate.

Despite its designation as having no medicinal use, Cannabis was distributed to patients by the U.S. government on a case-by-case basis under the Compassionate Use Investigational New Drug program established in 1978. Distribution of Cannabis through this program was discontinued in 1992.[1-4] Although federal law prohibits the use of Cannabis, the table below lists the localities that permit its use for certain medical conditions.

The main psychoactive constituent of Cannabis was identified as delta-9-tetrahydrocannabinol (THC). In 1986, synthetic delta-9-THC in sesame oil was licensed and approved for the treatment of chemotherapy-associated nausea and vomiting under the generic name dronabinol. Clinical trials determined that dronabinol was as effective as or better than other antiemetic agents available at the time.[7] Dronabinol was also studied for its ability to stimulate weight gain in patients with AIDS in the late 1980s. Thus, the indications were expanded to include treatment of anorexia associated with human immunodeficiency virus infection in 1992. Clinical trial results showed no statistically significant weight gain, although patients reported an improvement in appetite.[8,9]

Within the past 20 years, the neurobiology of cannabinoids has been analyzed.[10-13] The first cannabinoid receptor, CB1, was identified in the brain in 1988. A second cannabinoid receptor, CB2, was identified in 1993. The highest concentration of CB2 receptors is located on B lymphocytes and natural killer cells, suggesting a possible role in immunity. Endogenous cannabinoids (endocannabinoids) have been identified and appear to have a role in pain modulation, control of movement, feeding behavior, and memory.[11]

The effective chemical agents in cannabis that is being isolated for research are then described in this report:

“Cannabinoids are a group of 21-carbon–containing terpenophenolic compounds produced uniquely by Cannabis sativa and Cannabis indica species.[1,2] These plant-derived compounds may be referred to as phytocannabinoids. Although delta-9-tetrahydrocannabinol (THC) is the primary psychoactive ingredient, other known compounds with biologic activity are cannabinol, cannabidiol (CBD), cannabichromene, cannabigerol, tetrahydrocannabivarin, and delta-8-THC. CBD, in particular, is thought to have significant analgesic and anti-inflammatory activity without the psychoactive effect (high) of delta-9-THC.”

The report then goes on to outline several key potential benefits of cannabis that should be noted in the race for a cure for cancer, and also in the debate to further legalize cannabis in the United States.

Cannabis protects against cancer:

“One study in mice and rats suggested that cannabinoids may have a protective effect against the development of certain types of tumors.” They continue; “Cannabinoids may cause antitumor effects by various mechanisms, including induction of cell death, inhibition of cell growth, and inhibition of tumor angiogenesis invasion and metastasis. One review summarizes the molecular mechanisms of action of cannabinoids as antitumor agents. Cannabinoids appear to kill tumor cells but do not affect their nontransformed counterparts and may even protect them from cell death.”

Cannabis targets and kills lung cancer and breast cancer cells:

“An in vitro study of the effect of CBD on programmed cell death in breast cancer cell lines found that CBD induced programmed cell death, independent of the CB1, CB2, or vanilloid receptors. CBD inhibited the survival of both estrogen receptor–positive and estrogen receptor–negative breast cancer cell lines, inducing apoptosis in a concentration-dependent manner while having little effect on nontumorigenic, mammary cells.”

Cannabis has anti-inflammatory effects and may be beneficial for the treatment of colon cancer:

“In addition, both plant-derived and endogenous cannabinoids have been studied for anti-inflammatory effects. A mouse study demonstrated that endogenous cannabinoid system signaling is likely to provide intrinsic protection against colonic inflammation.[23] As a result, a hypothesis that phytocannabinoids and endocannabinoids may be useful in the risk reduction and treatment of colorectal cancer has been developed.[24-27]“

Cannabinoids may assist in the uptake of other cancer drugs, increasing their effectiveness:

“CBD may also enhance uptake of cytotoxic drugs into malignant cells. Activation of the transient receptor potential vanilloid type 2 (TRPV2) has been shown to inhibit proliferation of human glioblastoma multiforme cells and overcome resistance to the chemotherapy agent carmustine.[28] In an in vitro model, CBD increased TRPV2 activation and increased uptake of cytotoxic drugs, leading to apoptosis of glioma cells without affecting normal human astrocytes. This suggests that coadministration of CBD with cytotoxic agents may increase drug uptake and potentiate cell death in human glioma cells.”

Cannabis stimulates appetite:

“Many animal studies have previously demonstrated that delta-9-THC and other cannabinoids have a stimulatory effect on appetite and increase food intake. It is believed that the endogenous cannabinoid system may serve as a regulator of feeding behavior. The endogenous cannabinoid anandamide potently enhances appetite in mice.[29] Moreover, CB1 receptors in the hypothalamus may be involved in the motivational or reward aspects of eating.[30]“

Cannabis is an effective analgesic and pain medication:

“Cannabinoids may also contribute to pain modulation through an anti-inflammatory mechanism; a CB2 effect with cannabinoids acting on mast cell receptors to attenuate the release of inflammatory agents, such as histamine and serotonin, and on keratinocytes to enhance the release of analgesic opioids has been described.[34-36] One study reported that the efficacy of synthetic CB1- and CB2-receptor agonists were comparable with the efficacy of morphine in a murine model of tumor pain.[37]“

After presenting this important information the report then goes on to discuss the pharmacology of cannabis, a summary of clinical research on cannabis, and even the negative effects of it’s consumption, which do include a risk of cancer, although this is rather inconclusive.

As the report states, “cannabis has been used for medicinal purposes for thousands of years,” and only recently has it been targeted for prohibition. At a time when cancer is now the leading cause of death of children and cancer rates are climbing for everyone, those without safe access to medical cannabis absolutely deserve the right to add this to their medicine cabinet if they so choose.

Smoking cannabis will also help fend off diabetes

As reported by MSN online news (can’t believe it myself) smoking cannabis helps reduce the risk of diabetes, as well as reduced weight, control seizures, cure Crohn’s disease as well as a cancer. The article is below:

The magical weed that helps us stay trim, be less crazy, control seizures, cure Crohn’s, rescue the economy and make watching TV game shows more enjoyable is now being credited for possibly reducing the risk of diabetes, too. Analyzing statistics from the Centers for Disease Control and Prevention’s “National Health and Nutrition Examination Survey,” researchers uncovered the good news that current marijuana users had 16 percent lower fasting insulin levels and 17 percent lower levels of insulin resistance than their nonstoner friends. Bonus: Scientists found that pot users also had slimmer waistlines and higher levels of “good” cholesterol.

The claims of cannabinoids helping fight cancer and prevent its growth are documented here, here (in short video) and here. All you need to do is do a search online and there are organisations, reports and patents filed that confirm this. The article advises that smoking cannabis causes a reduced chance of diabetes but smoking is harmful to yourself unless using a vaporiser or eating said material. Ingestion of cannabis oil can be viewed as controversial as it flies in the face of those who are making monumental amounts of money, such as big pharma and private medical companies.

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I ask one simple question, what if there was a plant that we could all grow as a nation and that would render:

Industrial textiles
Paper
Building materials
Foods
Industrial products
Hygiene and beauty products
Animal feed
Horticultural products
Pharmaceuticals
Consumer textiles
consumer products

completely or marginally redundant? Shifting the balance of power away from corporations and onto people and communities. Conspiracy/Corruption are one and the same when it comes to preserving the hegemony of industrial and corporate power. If the claims I made were confirmed by mainstream media sources, open and transparent in the public gallery with results verified and available for all. I believe it would lead to a new dawn for man. Sounds dramatic but what if….

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